Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to crystalline defective structures such as oxygen deficiencies. However, fundamental understanding on structure-function relationship between crystalline/defective properties is still unclear. To address this, herein, we have developed an “in-situ confined oxidation-reduction” strategy regulate defect of molybdenum NPs dual-mesoporous silica nanoreactor. Especially, effects structure/oxygen defects oxides performances were investigated by facilely tuning amount resource reduction temperature. As a nanoagent, optimal encapsulated PEGylated porous nanoreactor (designated MoO3−x@PPSNs) exhibit excellent biological stability strong localized surface plasmon effect absorption range highest conversion efficiency up 78.7% under 808 nm laser irradiation. More importantly, remarkable MoO3−xPPSNs comprehensively demonstrated both vitro vivo. Consequently, envision that MoO3−x biocompatible nano-reactor could be used efficient therapy agent for ablation tumors.